Anti-RAF1 Polyclonal Antibody

商品货号：	商品品牌：	规格	基本售价：	选择规格
K000318P-50ul	solarbio	50ul	960.00元
K000318P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-RAF1 Polyclonal Antibody
别名	CMD1NN;CRAF;NS5;Raf-1;c-Raf
应用	WB IHC IF
稀释比例	WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
蛋白分子量	73kDa
Gene ID	5894
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human RAF1
性状	液体
Public Immunogen Range	Recombinant protein of human RAF1
Subcellular Locations	Cell membrane Cytoplasm Mitochondrion Nucleus
Swiss Prot	P04049
克隆类型	Polyclonal Antibody
背景资料	This gene is the cellular homolog of viral raf gene (v- raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.